Treatment of chronic myelogenous leukemia, finding the correct dose of the appropriate targeted agents after diagnosis is a condition for the best effect.
3/6/12 months after the first treatment started, a chromosome test via a bone marrow examination and quantitative BCR-ABL1 gene examination via blood will be performed.
The results of the genetic tests performed at each time point should show a gradual decrease of 10%, 1%, and 0.1%, and if the optimal curative effect is achieved, it will decrease to less than 0.1% within a year.
If treatment goes successful and a major Molecular Response is obtained, life expectancy is similar to a normal person. And if the treatment continues, the chances of obtaining less than 0.0032% of the BCR-ABL1 gene, the complete molecular response, are increased. Eventually, the chances of stopping targeted agents for a certain period will increase.
1drop's 1copy™ BCR-ABL qPCR Kit shows high precision and sensitivity in quanitative testing for CML. Capable of detecting BCR-ABL genes with high sensitivity - 0.0017% IS, the 1copy™ BCR-ABL qPCR Kit can stably detect and measure BCR-ABL1 levels at 0.0032% or lower (Complete Molecular Response). The 1copy™ BCR-ABL qPCR Kit has a short response time and is convenient,
due to its single-process reverse transcription and amplification response.
|Product||Detection range based on K562 RNA/test||Character|
|1copy™||o(100%)||o(100%)||o(100%)||o(100%)||o(95%)||o(88%)||o(56%)||△(13%)||x||1 step qRT PCR Kit|
|Competitor A||o(100%)||o(100%)||x||x||x||x||x||x||x||2 step qRT PCR Kit|
|Competitor B||o(100%)||o(100%)||x||x||x||x||x||x||x||Only for qPCR
|Detection range based on K562 RNA/test||100pg||o(100%)||o(100%)||o(100%)|
|Character||1step qRT PCR Kit||2step qRT PCR Kit||Only for qPCR
(RT reaction is not included)
Use only single tube for RT and real-time PCR
The 1copy™ BCR-ABL qPCR Kit allows for fast and convenient use
by detecting multiple mRNA targets in a single step.
|Total measurement time||2hours 25minute||3hours 30minute|
Our BCR-ABL qPCR Kit uses 1copy™
probes to ensure safe and accurate results.
The 1copy™ BCR-ABL qPCR Kit is highly sensitive, with CMR results above 0.0032% IS.
|Early Molecular Response
|Complete Cytogenetic Response
|Major Molecular Response
|12months||BCR-ABL < 0.1%|
|Deep Molecular Response
(Deep Molecular Response)
(Complete Molecular Response)
|after 12months||BCR-ABL < 0.0032%|
Primer Probe Mix
|Experimental step||Single step|
|Limit of Detection||4pg
|MR 4.77(MR value)|
|Target||4Species fusion mRNA
(b3a2, b2a2, e1a2, e19a2)
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